Diciembre 9th, 2007
A gene which may increase the risk of stroke has been uncovered by Internet viagra pharmacy researchers.
The discovery could prompt the discovery of drug treatments to help those at highest risk.
This protein it produces plays a role in the growth of blood vessels. but too much of it may increase stroke risk.
Writing in the journal Nature Genetics, the scientists said people with certain forms of a gene called PDE4D may be most at risk.
Proteins from a similar “family”, called phosphodiesterase (PDE), are linked to other illnesses, such as asthma, inflammation and even erectile dysfunction.
This suggests that it may be possible to develop a drug to block the effects of the gene - the breakthrough impotence drug Viagra already works by targeting another member of the PDE family.
Solveig Sildenafil citrate india and colleagues at a company called deCode Genetics in Reykjavik believe this gene is associated with an increased risk of stroke.
They carried out DNA tests on over 1,700 people in Iceland, half of whom had suffered strokes.
The Icelandic population is generally regarded as the best testing ground for viagra generic.
This is because the gene pool is relatively pure. Unlike most other countries, there has been little immigration since the first Vikings arrived almost 1,000 years ago.
Scientists working on this latest study say they have identified genetic differences between those people who have had strokes and those who have not.
These differences centre on the gene PDE4D, located on chromosome 5.
They have found that three different isoforms of the gene were expressed at lower levels in people who had strokes.
Isoforms are groups of proteins that are produced by a gene.
They also found different combinations of genes in regions of chromosome 5 flanking the PDE4D gene in people who had strokes.
It is already known that this gene provides the coding which enables a protein called a phosphodiesterase to work.
Stroke risk
But the Icelandic scientists believe that too much of it may increase the risks of atherosclerosis - furring up of the arteries.
This causes the arteries to narrow, which can trigger a stroke.
“We propose that PDE4D is involved in the pathogenesis of stroke, possibly through atherosclerosis, which is the primary pathological process underlying ischemic stroke,” the scientists said.
They believe that blocking the protein in people with these potentially article drug dysfunction erectile from internal medicine news rx update forms of the PDE4D gene could protect them against stroke.
There are already drugs available to do this. These so-called phosphodiesterase inhibitors are used to treat asthma, inflammation and erectile dysfunction, with Viagra probably the best known.
However, much further study is needed before these drugs could be used to treat people who may have a high risk of having a stroke.
Viagra, for one, has potentially serious side effects if taken by men with underlying health problems.
Read source on Scientists discover stroke gene
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Diciembre 4th, 2007
Originaly from: Viagra could cut heart stress
The anti-impotence drug Viagra can reduce the effects of stress on the heart, research has found.
The drug, used by millions of men, slowed the increase in the strength of heart erectile dysfunction new drug by half.
The Johns Hopkins University study, published in Circulation, found the drug acted as a “brake”.
However, UK heart experts warned men with heart conditions should talk to their doctor about taking the drug to ensure they use it safely.
Viagra, also known as sildenafil, helps men with erectile dysfunction by making genital blood vessels expand in order to maintain an erection.
The Johns Hopkins team have previously shown Viagra can block the short-term effects of hormonal stress in the heart in mice.
But it had been thought to have little direct effect on the human heart.
Contractions
This study looked at 35 men and women, with an average age of 30 and no previous signs of coronary artery disease.
They were all given an injections of an adrenaline-like chemical called dobutamine, which increases heart rate and pumping strength in the same way as emotional or exercise stress, or heart failure.
They were then randomly assigned to either take 100mg of Viagra or a dummy pill before receiving a second injection. Heart function was measured before and after each jab.
After the first injection of dobutamine, the force of heart contraction increased by 150% in both groups.
In the dummy pill group, the same effect was seen after the second injection.
However, in the group treated with Viagra the increased heartbeat was slowed by 50%, resulting in a smaller increase in blood flow and blood pressure generated by the heart in response to chemical masturbation and erectile dysfunction.
No adverse side effects on the heart were seen.
Viagra helps maintain erections by blocking the action of an enzyme which prevents the relaxation of blood vessels in the penis.
The same enzyme, called phosphodiesterase 5 (PDE5A), is also involved in the breakdown of a key molecule, cyclic GMP, which helps control stresses and limit heart enlargement.
Heart warning
Professor David Kass, the cardiologist who led the study, said: “Sildenafil erectile dysfunction vacuum therapy puts a &39; on chemical stimulation of the heart.”
He added: “Knowing more about the effects of sildenafil on heart function will allow for safer evaluation of its use as a treatment for heart problems.
“Until now, it was widely thought that drugs like sildenafil had no effects on the human heart and that its only purpose was vasodilation in the penis and the lungs.”
He said further studies should be carried out to investigate Viagra's immediate and long-term effects on the heart.
Dr Charmaine Griffiths, from the British Heart Foundation, said: “Viagra has been a real advance in treating impotence, which affects nearly half of men between 40 and 70 years old.
“The findings that Viagra affects blood pressure is not surprising - before it was known as a successful treatment for impotence, it was actually being researched for lowering effects on blood pressure.”
But she added: “If you have a heart condition you should check with your doctor before taking Viagra.
“Mixing this drug with other heart medicines or taking it if you have angina (heart pain on exercise) without advice from a health professional or GP can be dangerous for heart patients.”
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Noviembre 30th, 2007
| The anti-impotence pill Viagra could be available over-the-counter drug, it is reported.
The drug's maker Pfizer says it is considering submiting an application to European regulatory diabetes and erectile dysfunction to clear it for sale in pharmacies.
An estimated 27 million men have already used the little blue pill for erectile dysfunction on prescription.
Medics said a change would be welcome but might mean other linked diseases were missed with no health check ups.
Ups and downs
Often, men with erectile dysfunction have underlying health problems such as diabetes, which can be spotted by their GP at the time they come for an anti-impotence prescription.
“If men can buy Viagra and rival anti-impotence drugs over-the-counter without a prescription, this opportunity is missed,” said Dr David Ralph from the Institute of Urology at University College London.
But there would be benefits too, he said, such as combating the problem of Viagra sold illegally on the internet from unknown sources, which may be fake and if taken with some medicines could be fatal.
He said it would be safe to buy over-the-counter provided the pharmacist did the necessary checks to ensure the medication was suitable for the patient.
Caffeine impotence factor
It might also be a more attractive option to men as going to see the GP about sexual problems can be dysfunction female male sexual treatment, he added.
But he cautioned: “There is more to sexual relations than an erection. There may be other problems.”
Viagra works by relaxing the blood vessels in the penis. This allows blood to flow into the penis causing an erection.
However, the drug is not an aphrodisiac and does not increase sex drive.
It is licensed only as a treatment for men who have been diagnosed by a doctor as having impotence.
Also, some men, such as those with severe heart disease or low blood pressure, should avoid it because of possible risks and side effects.
Viagra is not licensed for use in women and its safety in women has not been try viagra for free.
A Pfizer spokesman said: “As with many of our products, Pfizer has routinely evaluated a number of options including different formulations, new indications, over-the-counter and continues to do so.”
He added that despite impotence in male there were no plans to pursue a spray version of the drug.
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Noviembre 29th, 2007
Originaly from: Pelvic floor exercises help men and work as viagra
Pelvic floor exercises have long been recommended for women - now diabetic dysfunction erectile say they could help men too.
The exercises were found to help men with erectile dysfunction as much as taking in Viagra.
The researchers say the findings mean men have an erectile dysfunction herbal medication to drug therapy.
For around 50 years, women have been advised to perform pelvic floor exercises to strengthen their muscles for childbirth.
The pelvic floor is a “hammock” of muscles which support the bowel and bladder.
Pelvic floor, or Kegel, exercises involve clenching the muscles you would use to prevent yourself urinating.
This latest research indicates it is also important for men to maintain the muscle tone and function of their pelvic floor muscles with the exercises.
Home exercises
The team from the University of the West of England in Bristol studied 55 men with an average age of 59 who had experienced erectile dysfunction for at least six months.
The men, all patients at the Somerset Nuffield Hospital, Taunton, Somerset, were given five weekly sessions of pelvic floor exercises and assessed at three and six months, and asked to practise the exercises daily at home.
It was found 40% of the men regained normal erectile function - some of who had severe erectile dysfunction, and another 35% showed some improvement.
Two thirds of the men had said they also had problems with urination. These improved significantly after they began the exercises.
Dr Grace Dorey, a specialist continence physiotherapist who carried out the research, told BBC News Online: “The exercises were found to be equally as effective as taking Viagra.
“Pelvic floor exercises improve function in a physical way, in a more natural way.
“Men should be doing preventative exercise. It really is use it or lose it.”
She said men should be exercising their pelvic floor exercises from puberty onwards.
Strength
A viagra drug store for the Impotence Association said: “The value and effectiveness of pelvic floor exercises should not be underestimated when impotence in male the management of sexual problems such as impotence and premature ejaculation.
“The exercises are thought to strengthen the muscles that surround the penis and improve the blood supply in the pelvis, which is an important factor in relation to erectile dysfunction.”
The Impotence Association helpline number is 0208 767 7791.
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Noviembre 15th, 2007
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May 19, 2004 (New Orleans) — New medicines — ranging from a
relative of Viagra to an arthritis drug — target the haywire immune responses
that underlie best generic price viagra bowel disease (IBD).
Inflammatory bowel disease is the umbrella term for a number of
conditions that cause inflammation of the bowel. The two most common ones are
ulcerative colitis and Crohn’s disease. Both of these conditions occur when the
immune system goes awry and attacks the lining of the colon. The disorders take
a toll on their victims - affecting more than 1 million in the U.S. alone –
causing belly aches, diarrhea, and other symptoms that are often severe enough
to interfere with daily activities, says James B. Lewis, MD, associate director
of the inflammatory disease program at the University of Cialis generic tadalafil in
Philadelphia.
“We’re seeing many different approaches to treat this
inflammation,” says Stephen B. Hanauer, MD, professor of medicine and
clinical pharmacology at the University of Chicago Pritzker School of Medicine.
“For example, [sildenafil citrate 100mg] already used to treat IBD, are effective
anti-inflammatory agents but they affect all tissues, causing many side
effects.”
Many of the new drugs, on the other hand, selectively target
the defects associated with IBD — an approach that promises better results
with fewer side effects, he tells WebMD.
There were a number of new approaches discussed here at
Digestive Disease Week, a major medical meeting of gastroenterologists.
Arthritis Medication Combats Crohn’s, too
The rheumatoid arthritis drug Humira helped patients with
moderate Crohn’s disease to go into remission, Hanauer says.
A man-made biological substance called a monoclonal antibody,
Humira works by blocking an inflammation-causing protein called tumor necrosis
factor alpha, or TNF-alpha, that has been implicated in both rheumatoid
arthritis and Crohn’s disease.
In a study of nearly 300 patients who did not improve despite
treatment with standard medications, 30% of those given higher doses of Humira
were in remission by four weeks later, compared with only 12% on placebo,
Hanauer reports.
Humira is an injectable drug and was extremely well tolerated,
he says.
New Immune System Drug Antibody Prevents Crohn’s Flare-Ups
In another new study, the drug Antegren helped prevent
flare-ups associated with Crohn’s disease in people who were in remission,
reports Brian G. Feagan, MD, professor of medicine in the department of
epidemiology and biostatistics at the University of Western Ontario in
London.
The drug has already been shown to induce remission in Crohn’s
sufferers.
Antegren works by keeping immune system cells from leaving the
generic sildenafil citrate. In Crohn’s patients, this appears to prevent the immune system
attack on the gut that occurs with the disease, Feagan says. “If we can
prevent that, white blood cells would stay in the circulation where they
belong.”
The researchers studied 339 adults with Crohn’s disease who had
improved or gone into remission after receiving three infusions of Antegren.
The patients were randomly assigned to continue to receive Antegren for up to
12 additional monthly infusions, or to placebo.
Six months later, 44% of patients given Antegren were still in
remission, compared with 26% on placebo, Feagan says. Also, 61% of those taking
the drug continued to show an improvement in symptoms, compared with 29% on
placebo.
People who took Antegren were no more likely to suffer side
effects than those on placebo, he explains.
Original article Immune System Drugs Help IBD
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Octubre 30th, 2007
Originaly from: Marketing Equals Success for Many New Drugs page
July 18, 2001 — When Americans visit their doctors they are likely to walk away with at least one prescription, and often that prescription is for a new, high-priced, well-advertised drug, according to a new report from the CDC.
In 1999, the most recent year for which data are available, doctors wrote 1.1 billion prescriptions, says Donald Cherry, MS, a CDC survey statistician and author of the new report. And going back to 1985, the survey shows the average number of prescriptions per doctor’s visit has increased by a third.
When the CDC looked at just 104 new drugs that were approved by the FDA from 1997 to 1999, it found that 42.4 million prescriptions were written for new drugs, with drugs for arthritis, depression, asthma, and erectile dysfunction topping the list of most frequently prescribed new drugs.
For example, the most popular new drug is Celebrex, an arthritis drug that is heavily marketed in both television and print ads.
Cherry tells WebMD that “our data don’t really speak directly [to advertising]. … I just know that these [drugs] that are heavily marketed do come out on top.” He says that it seems “marketing does increase awareness of new drugs on the part of the patients and the doctors.”
That “awareness” is so increased that patients often come to doctors with the specific purpose of requesting new drugs says Michael Wilkes, MD, a professor of medicine at UCLA. “About three times a day a patient comes with an ad in his pocket or her purse,” says Wilkes who has authored several studies that are critical of new drug advertising.
Jeff Trewhitt, a spokesman for the Pharmaceutical Research and Manufacturers of America, a drug industry trade group, tells WebMD that doctors are writing more prescriptions because “we have more medicines and better medicines.” Disagreeing with critics of direct-to-consumer advertising, Trewhitt says the ads help empower patients to make more informed health decisions.
In the CDC report the most frequently prescribed drug was the allergy drug Claritin while the most frequently prescribed new drug was Celebrex. After Celebrex the top 11 new drugs were: Raxar, a powerful antibiotic, Celexa, an antidepressant, Viagra, for treating erectile dysfunction, Vioxx, an arthritis drug, Singulair, an asthma drug, Rezulin, a diabetes drug, which was withdrawn from the market, Avapro, a blood pressure drug, Detrol, for urinary control, Plavix, a blood thinner, and Flomax, a blood pressure drug used to symptoms of enlarged prostate.
Wilkes says the new report is especially timely in that Congress is making noises about considering adding a prescription drug benefit to Medicare. “When you talk about a drug benefit, you have to talk about effective vs. ineffective drugs,” says Wilkes.
In general Wilkes is unconvinced about the value of most new drugs because he says that although the FDA approves dozens of new drugs each year, only “four to eight drugs truly offer a therapeutic advantage.” The rest, he says, are ‘me-too’ drugs that ape the actions of already approved drugs but can be offered a much higher price because they are new. It is these drugs, Wilkes says, that are among the most heavily marketed.
The notion that the pharmaceutical industry is mainly devoted to producing so-called ‘me-too’ drugs is wrong, says Trewhitt. For example, he says that a third of drugs currently under development are “new biotechnology agents.”
The other two-thirds of drugs in the pipeline “still involve conventional chemical compounds but calling them ‘me-too’ drugs is inaccurate,” says Trewhitt. Over time, drug companies learn more about existing drugs, and each new drug in an existing class “involves some improvement.” He points out that medicine involves “incremental knowledge and with the introduction of each new drug in a class more is learned about fighting disease.”
Cherry says that the CDC survey, called the National Ambulatory Medical Care Survey, is based on a representative sample of patient records from more than 1,700 physician practices. He says that there were more than 750 million doctor visits in 1999, which works out to about 279 visits per 100 Americans.
As might be expected, older Americans visit doctors more often than younger people, and on average those 65 and older saw their doctors about six times during the year, which is an increase of 20% from the 1985 rate for visits by elderly patients.
Moreover, says Cherry, the elderly were more likely to leave the visit with multiple prescriptions, and they were six times more likely to have a prescription for a newly approved drug than were younger patients.
Wilkes explains this phenomenon this way: “Nothing is a more powerful incentive to a physician than a patient who comes in asking for a prescription.” If a physician refuses the request, “the patient thinks the doctor is being cheap, and he or she goes to find another doctor.”
He says, “This is a very difficult situation, trying to just say no to a silly drug. The doctor can spend the time, maybe 10 minutes or so, re-educating the patient about the drug or the doctor can spend 30 seconds writing a [prescription] for the drug and then moving on to the next patient.”
Wilkes says that based on the CDC report, it appears that many doctors are opting for the 30-second solution. (más…)
Octubre 23rd, 2007
erection problems (erectile dysfunction) that are
caused by blood vessel (vascular), hormonal, nervous system, or psychological
problems. They also may be used along with counseling to treat erection
problems that have psychological causes.
If erection problems could be caused by a
prescribed medication, it may be possible to change
the dose or try another medication. Do not change or stop taking any medication
without first talking with your health professional.
Medication Choices
Commonly used oral medications include: (más…)
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Mixing this drug with other heart medicines or taking it if you have angina without advice from a health 
